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Guangzhou Southeast Science & Technology Co., Ltd. > Data Download > Preparation of 2020 Pharmacopoeia Xanthan Gum Viscosity Test

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Preparatory Pharmacopoeia Version 2020 Xanthan Gum Viscosity Test

Read: 2898 Release time: 2019/8/1 17:09:11
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版药典预稿黄原胶粘度测试 2020 Pharmacopoeia pre-draft xanthan gum viscosity test

Xanthan gum, as a kind of excellent biopolymer material, has strong application potential in pharmaceutical preparations. Xanthan Gum

Has good cohesion, can be mixed with starch, chitosan, locust bean gum and other auxiliary materials to prepare different viscosity, hardness, dissolution

Slow-release tablets are suitable for both water-soluble and non-water-soluble drugs, such as antipyretics, analgesics, anti-inflammatory drugs, and vitamins.

All can be mixed with xanthan gum to prepare sustained-release tablets.

What is the proper concentration of xanthan gum? Can interact with mucin, and then play a biological adhesion role, if higher viscosity

Can make patients feel uncomfortable. Pretreatment of xanthan gum solution by ultrasound can destroy the molecular structure of xanthan gum, which can promote its adhesion to

The protein response can reduce its viscosity and improve patient compliance. So in drug research, the viscosity test of xanthan gum

It is necessary to play one of the key factors influencing the efficacy of the drug.

2020 版药典预稿中,黄原胶的粘度测试方法如下 According to the preliminary draft of the 2020 Pharmacopoeia, the viscosity test method of xanthan gum is as follows

250ml ,置烧杯中,调节低螺距型搅拌器或磁力搅拌器的转速为每分钟 800 转,边搅拌 Take 250ml of water and place it in a beaker. Adjust the rotation speed of the low pitch type stirrer or magnetic stirrer to 800 revolutions per minute while stirring.

3.0g( 按干燥品计 ) 氯hua钾 3.0g 的混合物,继续搅拌 10 分钟,边搅拌边用 Slowly add a mixture of 3.0g of this product (based on dry product ) and 3.0g of chlorine hua potassium , continue to stir for 10 minutes, use while stirring

44ml 冲洗烧杯杯壁,停止搅拌,快速振摇烧杯,使烧杯上的颗粒完全浸入溶液中,调节 44ml of water rinse the wall of the beaker, stop stirring, quickly shake the beaker, so that the particles on the beaker are completely immersed in the solution, adjust

25±1 Temperature to 25 ± 1


800 转搅拌 2 小时(搅拌过程中可适当旋摇烧杯,以避免样品分层,每次旋摇 Continue to stir at 800 rpm for 2 hours (the beaker can be properly rotated during the stirring process to avoid sample delamination.

30 秒内,如供试品难以混合均匀,可适当延长搅拌时间)作为供试品溶液。 The time is controlled within 30 seconds, if the test product is difficult to mix uniformly, the stirring time can be appropriately extended) as the test solution.

25mm ,外筒直径为 27mm 的同轴圆筒旋转粘度计中,内 Take an appropriate amount of the test solution, and place it in a coaxial cylinder rotational viscometer with a barrel inner diameter of 25mm and an outer cylinder diameter of 27mm .

42mm ,以内分钟 18 转的转速或 1.885rad. 的角速度(或选择适宜的测 The tube is immersed in the sample to a depth of 42mm , at a speed of 18 revolutions per minute or an angular velocity of 1.885rad. (Or choose an appropriate measurement

24 ),依法测定(通则 0633 第三法 1 ),在 25 ℃时的动力粘度应不 The test conditions are such that the shear rate is 24 ), and it is determined according to the law (General Rule 0633 Third Method 1 ). The dynamic viscosity at 25 ℃ should not be

0.6Pa.s Less than 0.6Pa.s.

Recommended test viscometer

同轴圆筒形粘度计,满足测试要求型号为 RVDV2T SSA,SC4-18 转子、 TC-550MX BROOKFIELD coaxial cylindrical viscometer, meet the test requirements Model RVDV2T , SSA, SC4-18 rotor, TC-550MX ,

Optional software with audit trail function.

The advantage of this viscometer is that

)带嵌入式温度探针的标准样品杯,可以直接测量样品的温度 1 ) Standard sample cup with embedded temperature probe, which can directly measure the temperature of the sample

)用于控温的恒温循环水浴 2 ) Constant temperature circulating water bath for temperature control

)小量样品适配器具在指定的剪切率下进行准确粘度测量 3 ) Accurate viscosity measurement with a small sample adapter at a specified shear rate

du 家代理的博勒飞粘度计 DV2T ,粘度测量标杆, , shi 界。 The Boerfei viscometer DV2T , the agent of Southeast Science and Technology , is the benchmark for viscosity measurement . Spot supply, real price

Hui, technical services, free samples, perfect after-sales service.

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